Finally, pacritinib inhibits CSF1R kinase, disfavoring the differentiation of monocytes to macrophages thus,49 which promote myofibroblast survival and donate to the introduction of liver organ fibrosis
Finally, pacritinib inhibits CSF1R kinase, disfavoring the differentiation of monocytes to macrophages thus,49 which promote myofibroblast survival and donate to the introduction of liver organ fibrosis.50,51 Notably, controlling macrophage differentiation as an antifibrotic strategy in MF with a different pathway (using recombinant individual pentraxin 2) may be the subject matter of ongoing clinical analysis.52 Today’s…