Supplementary MaterialsbloodBLD2019001366-suppl1
Supplementary MaterialsbloodBLD2019001366-suppl1. CLL cells for 24 hours revealed Wnt5a-induced expression of interleukin 6 (IL-6), IL-8, CCL2, CCL3, CCL4, and CXCL1, which in turn could induce pSTAT3 in unstimulated CLL cells within 30 minutes. We found that Wnt5a could induce CLL cell expression of NF-B target genes, including IL-6, and that this effect could be blocked…