Both anti-ICOS mAbs bound to human ICOS expressing CHO-K1 (CCL61) cells (Figure ?(Physique1c)1c) but not to control CHO-K1 cells (Physique ?(Figure1d),1d), indicating the specificity of these two mAbs
Both anti-ICOS mAbs bound to human ICOS expressing CHO-K1 (CCL61) cells (Figure ?(Physique1c)1c) but not to control CHO-K1 cells (Physique ?(Figure1d),1d), indicating the specificity of these two mAbs. and normal control individuals achieved statistical significance. ICOS co-stimulation significantly increased the production of IFN-, IL-4 and IL-10 in both SLE and normal T cells. IFN- in…