Our observation from the specific intracellular itineraries in orthogonal and sliding endocytic settings implies that differential trafficking can certainly occur for the same receptor, indicating the existence of exclusive sorting mechanisms on the lateral plasma membrane

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Data Availability StatementSupporting data can be acquired through the corresponding author

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Since cancers stem cells (CSCs) were first identified in leukemia in 1994, they have been considered promising therapeutic focuses on for malignancy therapy

Since cancers stem cells (CSCs) were first identified in leukemia in 1994, they have been considered promising therapeutic focuses on for malignancy therapy. extracellular matrix, and exosomes, have been shown to be extremely important regulators of CSCs. Molecules, vaccines, antibodies, and CAR-T (chimeric antigen receptor T cell) cells have been developed to specifically target CSCs,

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