Supplementary MaterialsDocument S1
Supplementary MaterialsDocument S1. security by sequestering zinc into vacuoles. Interestingly, zinc-loading is definitely inhibited by IFNs-I, because a Janus kinase 1 (JAK1)-dependent suppression of zinc homeostasis affects zinc distribution in macrophages as well as generation of reactive oxygen species (ROS). In addition, systemic fungal infections elicit IFN-I reactions that suppress splenic zinc homeostasis, thus altering…