The most recent studies possess indicated a solid relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and gentle cognitive impairment

The most recent studies possess indicated a solid relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and gentle cognitive impairment. well mainly because energy homeostasis [12,14,24,27]. These results could be mediated by two main components of the mind insulin transduction systems: phosphatidylinositol-3-kinase (PI3K)/Akt pathway and mitogen-activated proteins kinases/Ras pathway (MAPK/Ras) [12,28].

Supplementary Materials Table?S1

Supplementary Materials Table?S1. executed in patients not selected for having kidney disease. Slopes of serum creatinine reciprocals representing steps of kidney function switch ([mg/dL]?1/y), were analyzed in 30?621 patients. Based on treatment arms, patients were categorized into 3 groups: placebo (n=10?057), atorvastatin 10?mg daily (n=12?763), and 80?mg daily (n=7801). To assess slopes, mixed\model analyses were