Supplementary MaterialsFigure 5-1
Supplementary MaterialsFigure 5-1. PIP2-gated G-protein combined rectifying K+ currents aswell inwardly. Scarcity of KCNQ2-comprising M-channels ablated the M1R-induced enhancement of M-current in DGGCs. Simultaneously, M1R activation in DGGCs induced powerful raises in [Ca2+]i, mostly due to TRPC currents, consistent with, and contributing to, neuronal depolarization and hyperexcitability. CA1 neurons did not display such multimodal signaling,…