While the mechanism of cytotoxicity was not clear, it was proposed that the antibodies bind to DFS70/LEDGFp75 released into the extracellular environment, preventing its re-entry into LECs where it acts as a pro-survival factor
While the mechanism of cytotoxicity was not clear, it was proposed that the antibodies bind to DFS70/LEDGFp75 released into the extracellular environment, preventing its re-entry into LECs where it acts as a pro-survival factor. their significance remains elusive. DFS70/LEDGFp75 has emerged during the past decade as a stress transcription co-activator relevant to HIV integration, cancer,…