Data Availability StatementNo data are associated with this article. public health interventions will be possible. Current diagnostic tools have inadequate test performance, meaning that most individuals with TBM are either not diagnosed or diagnosed late, once significant cerebral damage has occurred. Current antimicrobial treatment is based mainly on the treatment of pulmonary TB with little consideration to mode of drug action or CSF penetration. Given that most damage caused by TBM is due to host inflammation, it is anticipated that host-directed therapies should play an important role in modulating the damaging immune-medicated effects. However, other than corticosteroids, no agent has been demonstrated to be effective in reducing mortality and corticosteroids have not been shown to improve long-term morbidity 2. The critical care management of TBM is also poorly understood, with highly divergent practice in the management of raised intracranial pressure, hydrocephalus, blood pressure, oxygenation and hyponatraemia 3. Understanding the perfect administration of the areas would probably enhance the long-term result of diagnosed individuals. Finally, the management of TBM within health systems is sub-optimal with services and tools rarely provided at the locations where patients present. Public sensitisation is infrequently undertaken, and clinical training is often limited. Globally, there are relatively few researchers of TBM and only a small number of centres of excellence. The field, therefore, ALLO-1 would benefit from greater co-ordination, collaboration and data sharing. In 2009 2009, the TBM International Research Consortium was fulfilled and shaped for the very first time in Cape City, South Africa. Following meetings occurred in 2015 in Dalat, Vietnam, and in 2019 in Lucknow, India. The Consortium provides approximately 50 experts from five continents together. In the Lucknow conference, the Consortium experienced that it might be helpful to develop a record detailing study priorities in TBM. The practice of creating understanding spaces and priorities for study helps researchers to target attempts on areas that are recognized to become probably to result in clinical benefit. It allows funders to focus on their financing also. This practice may also be good for advocacy through a clearer message and co-ordinated plan. In this specific article we describe the procedure of creating a TBM study plan and format ALLO-1 the priorities which were created. Identifying understanding gaps and study priorities for TBM The 3 rd TBM International Study Consortium occurred in Lucknow for the 1 st and 2 nd March 2019. Through the conference, study improvements were presented by leading clinicians and analysts in each respective field. Each have been requested to additionally present their thoughts and ideas for understanding gaps and study priorities for the reason that field. Pursuing each presentation, controversy around these priorities and spaces occurred. After the conference, these priorities had been assimilated into dining tables of study gaps with a primary composing group, with spaces grouped in to the styles of epidemiology, pathogenesis, analysis, antimicrobial therapy, host-directed therapy, important care and treatment cascades. For every understanding gap, study styles were proposed that may address them. These dining tables had been circulated to the complete consortium who have been asked to supply insight and make recommendations concerning which areas had been the highest concern. Through further cycles of dialogue inside the composing group, the dining tables of understanding gaps were up to date ( Desk 1C Desk 7) and a consolidated set of top priorities for TBM research was developed, which are presented in Table 8. This article describes the knowledge gaps and research priorities for TBM. Table 1. Knowledge gaps in the epidemiology of tuberculous meningitis. impact on disease models including isolated cell populations, blood brain barrier models and cerebral organoids. B. models including zebrafish, mice, rabbits and non-human primates. C. Correlates of protection studies in humans. D. Observational, diagnostic and randomised intervention studies in humans. Table 3. Knowledge gaps in the diagnosis of tuberculous meningitis. derived in CSF? Host-response models including isolated cell populations, blood brain barrier models and cerebral organoids. B. models including zebrafish, ALLO-1 mice, rabbits and non-human primates. C. Correlates of protection studies in humans. D. Observational, diagnostic and randomised intervention studies in humans. Table 5. Knowledge gaps in the use and understanding of host directed therapies for tuberculous meningitis. versions, including rabbits and mice versions, including rabbits and mice versions, including rabbits and mice versions, including rabbits SCA27 and mice is currently the most frequent reason behind bacterial meningitis in a few high TB burden configurations 5, pursuing wide execution of regular vaccinations to meningococcus,.